INFO:

The composition of the immune repertoire, consisting of the T cell and B cell receptors (TCR and BCR), is important for an organism's adaptive immune system and plays a pivotal role in an individual's overall health. Understanding the complex array of TCR and BCR allows for developing precision medicine and immunotherapy. Analyzing next-generation sequencing (NGS) data from RNA-seq experiments to characterize and understand TCR and BCR clonotypes may aid in identifying cases that could benefit from personalized immunotherapy or potentially predict therapeutic outcomes.